- NDRI Drugs: Depression Medication
- So, what does that mean in plain english?!
- NDRI Drugs List
- Most Common Side Effects of NDRI’s
- Antidepressant Warnings
- HELPFUL TIP
- Facts about Wellbutrin, an anti-depression medicine | | Expert help for your emotional health | Expert help for your emotional health
- What is Wellbutrin?
- What is treatment with Wellbutrin ?
- What are some best practices for taking Wellbutrin?
- What are the dosages?
- What are some possible side effects?
- What are some other drug interactions?
NDRI Drugs: Depression Medication
NDRI stands for Norepinephrine-Dopamine Re-uptake Inhibitor.
NDRI drugs are similar to SSRIs and SNRIs, as in, they are said to “inhibit the re-uptake” of certain neurotransmitters (messenger molecules). However, in this case, instead of Serotonin being inhibited, it’s Norepinephrine + Dopamine. Hence the name, Norepinephrine-Dopamine Re-uptake Inhibitor (NDRI).
So, what does that mean in plain english?!
Well, this act of inhibiting the natural recycling process of Norepinephrine + Dopamine is said to increase the availability of these neurotransmitters (messenger molecules) within the brain, which is believed to alleviate the ‘symptoms’ of depression.[divider style=”6″]
- Want to see the basic process of how “re-uptake inhibitors” are said to work to treat depression? Then, be sure to watch: How Do Antidepressants Work?
NDRI Drugs List
Norepinephrine–dopamine re-uptake inhibitors (NDRIs) are used for clinical depression, attention deficit hyperactivity disorder (ADHD), narcolepsy, smoking cessation and as anti-parkinson agents.
Here’s a list of some commonly prescribed NDRI drugs.
- Bupropion – Wellbutrin – Zyban – Elontril – Budeprion – Aplenzin – Voxra – Forfivo – Prexaton – Quomem – Zyntabac – Carmubine
- Dexmethylphenidate – Focalin – Attenade – Concerta (Lithuania)
- Methylphenidate – Concerta – Ritalin – Metadate CD – Medikinet – Matoride XL – Equasym – Medicebran – Daytrana – Difumenil – Biphentin – Aptensio XR – Methylin – Motiron – Quasym – Quillivant XR (NOTE: Known to act as a DNRI dopamine-norepinephrine reuptake inhibitor. In other words, it acts on dopamine more than norepinephrine).
Most Common Side Effects of NDRI’s
NDRI’s may cause:
- Nausea / vomiting
- Feeling agitated, shaky or anxious
- Diarrhoea or constipation
- Dizziness / Lightheadedness
- Blurred vision
- Increased risk of suicidal thinking &/or suicidal behaviour
- Cognitive &/or memory impairment
- Lack of interest, enthusiasm or concern
- Inability to feel pleasure in normally pleasurable activities
- Emotional blunting
- Dry mouth
- Weight loss
- Weight gain
- Lack of energy / fatigue
- Decreased libido
- Sleeping disturbance (insomnia)
- Abnormal dreams or vision
- Excessive sweating
- Sexual dysfunction
- Abnormal ejaculation
- Difficulty passing urine
- Bruising or bleeding easily
- Movement troubles, such as; stiffness or shaking
- Myalgia (muscle pain)
- Abnormal physical weakness
- Low blood pressure
- Tremors or muscle twitches
- Abdominal pain
- Skin reactions / rashes
- Hyponatremia (low sodium blood levels)
- Cold / flu- symptoms
- Sinus, nose or upper respiratory infections
- Manic switch (switching of mood into mania)
- Increased risk of seizures
- Increased risk of gastrointestinal (stomach/intestinal) bleeding
- Increased risk of Serotonin Syndrome.
NB. Although there are no documented cases of Serotonin Syndrome following Bupropion/Wellbutrin/Zyban ingestion alone in the literature, the ability of Bupropion/Wellbutrin/Zyban to potentiate serotonin levels and lead to Serotonin Syndrome is known. [divider style=”6″]
Antidepressant drugs can interact with other medications, foods and natural supplements (for example; St Johns Wort) which may increase the risk of Serotonin Syndrome, so be sure to speak to your doctor or healthcare provider to ensure there’s no negative interactions.
If you would to personally assess how your medications may interact with each other, then simply click here to use the FREE Drug Interactions Checker. This will inform you of any possible negative interactions of your medications.
NOTE: Always consult your healthcare provider to ensure the information displayed on the Drug Interactions page applies to your personal circumstances. Always check with your healthcare provider to determine if any adjustments to your medications are needed.
WARNING: *** NEVER stop an antidepressant drug without first consulting your healthcare provider. Suddenly stopping an antidepressant drug can cause adverse effects.***
NOTE: The content on this page is for general information purposes only. This page is not intended to give advice regarding NDRI Antidepressants (NDRIs).
Facts about Wellbutrin, an anti-depression medicine | | Expert help for your emotional health | Expert help for your emotional health
By Dr. Ho Anh, 07/22/2020
Chances are, you know someone who takes some sort of psychiatric medicine. According to the National Center for Health Statistics, 12.7% of the U.S. population over age 12 in 2017 took antidepressants in the past month and one in six Americans take some sort of psychiatric drug.
With the prevalence of antidepressants, how do we distinguish between the many types? Wellbutrin is a norepinephrine-dopamine reuptake inhibitor (NDRI) that stands out among the host of selective serotonin reuptake inhibitors (SSRIs), which are the most common drug for depression treatment. SSRIs are known to come with side effects nausea, insomnia, diarrhea, weight changes, and nervousness.
While SSRIs are also notorious for their unwanted influence on libido and orgasms, Wellbutrin is an antidepressant alternative that has been shown to cause fewer sexual side effects and can even improve sexual function in some cases.
What is Wellbutrin?
Wellbutrin, or bupropion, is an NDRI antidepressant that is FDA approved to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). The drug is prescribed off label to help with bipolar disorder and attention deficit hyperactivity disorder (ADHD).
Because it has also been known to help people quit smoking, the drug could be a good choice for those who are affected by mood disorders and want to quit smoking. Wellbutrin comes in the form of an oral tablet.
What is treatment with Wellbutrin ?
Much most medication for mood disorders, Wellbutrin works most effectively to decrease the symptoms of depression over the course of a few weeks. In the first 1-2 weeks, physical symptoms related to energy levels, sleep, or appetite tend to improve first, followed by mood improvement and renewed interest in activities in 4-6 weeks.
For long-term improvement, it's important to keep using bupropion even after symptoms have subsided to ensure depressive symptoms don't return.
However, if you're taking Wellbutrin to quit smoking, the period of use may be shorter.
Please consult your provider on the length of your treatment and do not stop taking or change the dosage without asking your healthcare provider first.
What are some best practices for taking Wellbutrin?
When taking medication that may affect your mood and behavior, it's important to be diligent about how and when you're taking it. Here are some best practices for taking Wellbutrin:
- If you miss a dose, take it as soon as you remember. Never take two doses at once.
- Avoid alcohol consumption and illegal drug use. It may reduce the effectiveness of the medication and increase the risk of seizures.
- Do not stop taking Wellbutrin abruptly. The risk of seizure from stopping abruptly is four times greater with Wellbutrin than other depressants.
What are the dosages?
There are three formulations and dosing variations. Please consult your doctor to find the appropriate treatment:
- Immediate release: Wellbutrin is immediate release for MDD, which means it takes effect shortly after the tablet is taken. Dosage can be up to three times a day. A dose usually starts at 100mg twice a day up to three times a day at max 150mg per dose.
- Sustained-release: Treats MDD. Dosage is typically 150mg once a day, potentially 150mg (max 200mg) per day.
- Extended-release: Treats MDD and SAD, starting at 150mg (max 300mg or 450mg) once a day.
What are some possible side effects?
Side effects are usually resolved in the first 1-2 weeks of treatment and are typically mild. Un many antidepressants, Wellbutrin does not typically lower libido or cause sexual side effects and is often prescribed along with other antidepressants to counter the sexual side effects other drugs might have. For those with bipolar disorder, Wellbutrin may lead to manic episodes.
The most common side effects are:
- Dry mouth
- Stomach pain
- Sleep difficulties
- Weight loss
- Reduced appetite
- Nausea and dizziness
Rare side effects occur in less than 10% of patients and include:
- Muscle pain
- Skin rash
- Ringing in the ears
- Angle-closure glaucoma
- Skin rash
What are some other drug interactions?
Other drugs may influence how Wellbutrin works or increase side effects:
- Blood thinners
- Diabetes medications (Glucophage)
- Monoamine oxidase inhibitors
- OTC pain relieves (e.g. ibuprofen)
Please consult a medical professional to see if Wellbutrin is a good fit for your condition.
Dr. Ho Anh
Chief Medical Officer at Cerebral