How Long Does Tramadol Stay in Your System?

How Long Does Tramadol (Ultram) Stay In Your System?

How Long Does Tramadol Stay in Your System?

Tramadol stays in a person’s system for about a day and a half. This drug is an opioid painkiller that is often sold under brand names such as Ultram, Conzip, or Ryzolt.

It’s difficult to know the exact amount of time that tramadol will be detectable, as this can be influenced by factors such as height, weight, age, and overall health. For example, if a person has a low-functioning kidney or liver, it will take longer for their body to process the medication.

Tramadol Half-Life

Although tramadol can stay in a person’s system for nearly two days, this drug has a half-life of 6.3 hours. This means that after six hours have passed, half the dose will remain in a person’s system.

Tramadol is often prescribed by physicians, as it is widely believed to be less addictive than other opioids. However, people can still become dependent on this medication.

If you or someone you love is unable to stop taking tramadol, you may want to consider an Vertava Health rehab program.

We can help you explore treatment options, find the right rehab center, and design a plan that meets your needs.

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How Long Does Tramadol (Ultram) Take To Work?

Tramadol is a fast-acting medication. People who take tramadol will ly feel the effects of the drug within 30-60 minutes. The peak concentration of tramadol is reached within two hours. This means that within the first hour or two after a person takes tramadol, they will ly experience side effects analgesia (lessened pain) and sleepiness.

Drugs tramadol are metabolized by the liver. If a person’s liver is well-functioning, this organ will then break tramadol down into agents called metabolites. Depending on a person’s metabolism and organ function, some may feel the drug’s effects faster than others.

Tramadol (Ultram) Detection Time

Tramadol can be detected in a person’s system anywhere from one to 36 hours after last use. This is an average estimate that can be impacted by a person’s body size, age, and metabolism.

People may be curious about tramadol detection time for several reasons. If a person has an upcoming drug screening, they may want to ensure the medication is cleared from their system.

Many workplaces and medical offices require drug screenings for a variety of reasons. If you have a legal prescription for tramadol and are worried about failing a drug test, simply alert the person administering the test to your prescription. They may ask for a copy of the prescription for their records.

Another reason people may wonder how long tramadol stays in the system is because of the other medications they take. Opioids tramadol can be extremely dangerous when taken with other drugs, especially benzodiazepines.

Tramadol may also cause side effects such as dry mouth, insomnia, or headache. As the body processes the drug and peak levels decrease, these effects should diminish.

Drug Test Types That Detect Tramadol (Ultram)

Opioid analgesics tramadol can be habit-forming. If a person takes tramadol for a long period of time, their body may begin to crave a higher dose of the drug. While less addictive than other opioids, tramadol should still be taken with caution.

This medication can result in tolerance, dependence, and addiction. Because of this, schools, doctors, and employers may require routine drug screenings that test for this opioid.

There are multiple drug screen types that can detect opioid- tramadol, including:

  • Urine Screening: This is the most common type of drug test, and usually shows results from the past one to three days
  • Saliva Swab: Oral swab tests can detect tramadol for 24-36 hours after last use
  • Hair Test: While it’s uncommon to use a hair test for tramadol, hair follicle screenings can often detect substances up to 90 days after use

If you are unable to stop taking tramadol without experiencing withdrawal symptoms, you are ly dependent on the medication. Fortunately, effective treatment is available.

Factors That Influence How Long Tramadol (Ultram) Is In Your System

other prescription medications, people’s bodies have different reactions to tramadol. This can include how long the drug stays in a person’s system. Genetics, overall health status, and size can all play a part in determining how long tramadol will remain in your body.

Tramadol detection time can be altered by additional factors, including:


Elderly people have slower metabolisms, which can impact how long tramadol remains in a person’s system. Additionally, people of advanced age may have lower functioning kidneys and liver, which means it will take longer for the body to clear the medication.

Amount Taken

People who take tramadol for an extended amount of time may have traces of the drug in the fatty tissues of the body. If a person takes large or frequent doses of the drug, tramadol will remain traceable for a longer period of time.

Body Mass Index (BMI)

Because tramadol is stored in the body’s fatty tissues, those who have a higher body mass index may have larger amounts of the drug in their system. A person’s BMI may also impact their overall organ function, including the rate at which their liver metabolizes drugs tramadol.

How To Get Tramadol (Ultram) Your System

The safest way to get tramadol your system is with the help of a medical detox program. People who know they have an upcoming drug screening may attempt to stop taking the drug on their own, which can lead to acute withdrawal.

Opioid withdrawal can be difficult and uncomfortable. People who stop taking tramadol abruptly may experience symptoms chills, nausea, vomiting, and anxiety.

It can be difficult to stop taking opioids tramadol. Medically assisted detox programs can provide the support and supervision needed by people who are suffering from tramadol abuse and addiction.

In a medical detox setting, doctors may suggest a tapering schedule. This allows the patient to slowly decrease their dose of tramadol, in order to give their body time to adjust to not having the drug.

Even when a person tapers off slowly, they may still experience painful withdrawal symptoms. In a detoxification program, patients are provided with medication-assisted treatment that helps to relieve flu- withdrawal symptoms.

Getting Treatment For Tramadol (Ultram) Abuse And Addiction

Many people can take tramadol without any issue. However, millions of Americans are currently battling an opioid use disorder. If you or someone you love is suffering from tramadol abuse, an inpatient rehab program can help.

Vertava Health provide on-site detox programs, at our rehab centers throughout the U.S. Once a person successfully detoxes from tramadol, they benefit by engaging in a blend of traditional and alternative therapies. Individual counseling, wilderness therapy, and 12-step support groups are offered at our inpatient rehab centers.

To learn more about how long tramadol stays in your system, or to find a rehab program near you, contact an Vertava Health treatment specialist today.


How Long Tramadol Stays in Your System: Urine, Hair, etc

How Long Does Tramadol Stay in Your System?

Tramadol, which is the generic name for Ultram or Conzip, is a chronic pain relief medication. all narcotics, it works by binding to opioid receptors in the brain. It has been used to treat moderate to severe pain since the 1960s for its analgesic properties.

Since 2016, there have been over 120 million tramadol prescriptions in the United States. Tramadol is considered safe to use because it has a low potential for addiction and abuse at prescribed doses, though addiction is still possible. The pain-relieving effects are far less than more intense opioids codeine.

However, Tramadol poses several potential health complications for both casual and excessive users. 

How Long Does It Take to Feel the Effects of Tramadol?

Tramadol works on the opioid pain receptors located in your brain and throughout your central nervous system. It also weakly reduces the reuptake of two neurotransmitters: serotonin and norepinephrine. The pain relief effects start approximately an hour following a dose and peak in two to four hours.

There are also extended relief forms of Tramadol that distribute dosages in phases over a longer period. This means that a single extended relief pill is present longer in your system. While it is active, tramadol depresses breathing and causes the pupils to constrict.

Tramadol reduces movement in your digestive system, so food takes longer to digest. You may experience constipation. Tramadol also dilates your blood vessels, so you may experience flushing, itching, sweating, and dizziness or faintness when you get up after lying down.

How Long Does Tramadol Stay in Your System?

The amount of time any drug remains in the body can vary individualized factors. I.E., body composition, lifestyle, etc. The half-life of Tramadol in moderate drug use is 5 and 9 hours.

Urine Drug Test

Urine tests can detect the presence of Tramadol in the system. Tramadol stays in the urine for 1 to 4 days (24 to 72 hours).

Hair Drug Test

It is still possible to detect Tramadol in hair follicles for up to 90 days after the last use. Hair tests are generally used to support urine test findings. Hair tests also increase the detection window as most drugs are flushed the system within a few days to a week.

Saliva Drug Test

Saliva tests for Tramadol can detect the drug anywhere from 24-48 hours after the last dose. Saliva drug screens are rare due to the short window of detection. 

Blood Drug Test

Blood tests, except to test for alcohol, are expensive and only detect recent use. It’s unly that a person will receive a blood test for Tramadol. Tramadol stays in the blood for up to 48 hours.

Factors That Affect Detection Time

For some individuals, it takes significantly longer to break down tramadol. Factors that can affect Tramadol’s detection time include:


Higher doses of Tramadol take longer to metabolize.

Frequency of Use

Tramadol collects in the body as more doses are taken. If some of the previous doses have not entirely broken down, your body will ly take longer to metabolize the extra quantities.


A slower metabolic rate heightens the amount of time it takes tramadol to break down. Activity level, body composition, and diet can all affect metabolism.

Reduced Kidney or Liver Function

Impairment of the body's organs to remove waste will increase the amount of time Tramadol remains in the body.

Route of Drug Administration

Generally, tramadol injections or drops are quickly absorbed and excreted faster compared to tramadol in pill form.

What are the Side Effects of Tramadol?

Tramadol can produce a high when taken in excess. However, as an opioid, Tramadol disrupts certain brain functions and can severely strain bodily organs. Here are the most common side effects of Tramadol use:

  • Vomiting
  • Nausea
  • Headache
  • Dizziness
  • Irritability
  • Dry mouth
  • Constipation
  • Lethargy 
  • Heart issues
  • In rare cases, hallucinations, anxiety, and shakiness.

Tramadol's side effects can vary individual health factors and body composition.

Can Tramadol Cause Long-Term Damage?

Just other prescription pain medications, Tramadol drug use can cause long-term damage, especially in cases of substance abuse. Here are the most common long-term effects:

Liver damage — Tramadol use can cause acute liver failure. This condition can be fatal. However, even in cases where the person survives, liver failure tends to scar liver tissue, and the risk for liver failure and liver cancer increases significantly. 

Kidney damage — In cases of chronic drug use, Tramadol harms the kidney. Once filtered through the kidney, Tramadol can leave behind trace elements, known as metabolites, that in excess begin destroying healthy kidney cells. This form of kidney damage takes place over a longer period of tramadol addiction.

Substance dependency — In moderate use, Tramadol has little to no addictive properties. However, Tramadol abuse can lead to addiction.

Additionally, in rare cases, Tramadol causes substance dependency in individuals that had no prior substance dependencies.

 Addiction and dependency may cause withdrawal symptoms when a person decides to stop using the drug abruptly.

Behavioral changes — Substance misuse/abuse changes the way the brain works. It can rewire the reward center and cause extreme prioritization of the drug. Tramadol withdrawal can cause psychosis

Seizures — Although rare, Tramadol can cause seizures after taking high or low doses. 

Heart damage — Tramadol has been linked to serotonin syndrome. This is a condition characterized by an overabundance of serotonin in the brain resulting in anxiety, jitters, heart rate issues, and in extreme cases, hospitalization. 

How Is Tramadol Eliminated From The Body?

Tramadol elimination is a two-part process. It begins in the liver, where the body processes the drug. Tramadol, in particular, is heavily processed by the body. When taken orally, Tramadol is over 60% bioavailable. 

After multiple doses, the bioavailability can exceed 90%. This means that the liver processes Tramadol so thoroughly that it is easily and widely absorbed into a person’s system.

The second part of the elimination happens in the kidney. The result is metabolites, essentially what’s leftover from the processing. In cases of excess or tramadol abuse, these metabolites build up and wreak havoc on the body.

Symptoms of Tramadol Overdose

The best (and the only) way to remove Tramadol from your system is to stop taking the drug altogether. This will give your body time to process the drug and eliminate it.

To prevent Tramadol overdose, healthcare professionals recommend that you only take the correct dosage at the correct schedule as prescribed by your doctor. If you suspect a Tramadol overdose, look for these signs and symptoms:

  • Breathing problems (slow, erratic, shallow, or stopped)
  • Cold, clammy skin
  • Cyanotic (bluish) lips and fingernails
  • Gurgling, snore- noise or choking sounds
  • Muscle weakness
  • Non-responsiveness to any form of stimuli
  • Pupillary constriction
  • Slow, erratic, or undetectable pulse or heartbeat
  • Seizures
  • Unconsciousness

Drug dependence, drug interactions, drug misuse, and addiction can all lead to Tramadol overdose. If you know someone who needs addiction treatment, seek help to get professional medical advice. In many cases, addiction therapy is needed to assist recovery.

Treatment Options for Opioid Abuse & Addiction

There are several options for people suffering from opioid addiction. These include:

Medication-Assisted Therapy (MAT)

There are three medications approved to treat opioid use disorder: buprenorphine, methadone, and naltrexone.

Buprenorphine and methadone can help you manage withdrawal symptoms throughout the detoxification process.

Naltrexone is less commonly used, but it blocks your opioid receptors, making it impossible to get high. Medication-assisted therapy is most effective when combined with other forms of treatment.

Inpatient Programs

Inpatient programs are the most intensive and effective treatment options for opioid addiction.

These programs guide you through medically supervised detoxification, then behavioral therapy and other services (possibly including MAT), will be added to your treatment.

They typically last 30, 60, or 90 days. However, they may be longer if necessary.

Partial Hospitalization Programs (PHPs)

PHPs are also known as intensive outpatient programs (IOPs). They are the next most intensive type of treatment for opioid addiction. They provide similar services to inpatient programs such as detoxification, behavioral therapy medical services, and custom treatments such as MAT.

The difference is that in a PHP, the patient returns home to sleep. Some programs will include transportation and meals, but this varies by program.

Partial hospitalization programs are helpful for both new patients and patients who have completed inpatient treatment and still need intensive recovery therapy.

Outpatient Programs

Outpatient programs work best for people who have a high level of motivation to recover. They create treatment programs that work around your schedule.

These programs can either be an effective treatment option for new patients or a part of an aftercare program for people who complete inpatient or partial hospitalization programs.

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